What Does The Research Say?

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Published Research 

Papers that inform our practice 

There is an abundance of published literature describing conditions involving fibrosis of soft tissues. On this page we have provided links to various papers that discuss everything from the conditions that set up fibrosis formation, all the way through to the painful chronic conditions that result.

These papers are technical in nature and not always easy reading! Much of the literature describes surgical reduction of soft tissue adhesion, where-as in our office we work by hand towards the same outcome.

Shockwave Therapy (ESWT) - Pain Relief & Tissue Regeneration

https://pubmed.ncbi.nlm.nih.gov/32464597/

https://pubmed.ncbi.nlm.nih.gov/24782334/

https://pubmed.ncbi.nlm.nih.gov/26122717/

https://pubmed.ncbi.nlm.nih.gov/30756165/

https://pubmed.ncbi.nlm.nih.gov/30756165/

Senolytics https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939651/

https://bjsm.bmj.com/content/52/9/566

https://idp.springer.com/authorize?response_type=cookie&client_id=springerlink&redirect_uri=https://link.springer.com/article/10.1007/s40279-020-01308-6

https://pubmed.ncbi.nlm.nih.gov/27984030/

ow.ly/j7YK50BeoOm

https://www.mdpi.com/1422-0067/20/10/2446/htm

10.1177/2325967119S00132

https://pubmed.ncbi.nlm.nih.gov/24614255/  CDR prog

https://pubmed.ncbi.nlm.nih.gov/31731008/  medic changes/neck pain

https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-019-2835-2 load and deg.

https://downloads.hindawi.com/journals/bmri/2021/5937250.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074373/pdf/jcm-09-00568.pdf

https://bmcmusculoskeletdisord.biomedcentral.com/track/pdf/10.1186/s12891-019-2525-0.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989278/pdf/586_2010_Article_1411.pdf

https://thejns.org/view/journals/j-neurosurg/129/3/article-p815.xml?tab_body=pdf-22208

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106907/pdf/BMRI2020-2064781.pdf

https://josr-online.biomedcentral.com/track/pdf/10.1186/s13018-019-1290-y.pdf

https://bmcmusculoskeletdisord.biomedcentral.com/track/pdf/10.1186/s12891-018-2204-6.pdf

https://online.boneandjoint.org.uk/doi/full/10.1302/2046-3758.98.BJR-2019-0365.R1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686643/pdf/10.1177_2325967120903430.pdf

Chronic Conditions, Diagnostic, & Treatments

Sciatic Nerve Entrapment due to Fibrous Adhesion in the Deep Gluteal Space: Proposed Clinical Diagnostic Criteria and Therapy Using Manual Adhesion Release®

The endoscopic treatment of sciatic nerve entrapment/deep gluteal syndrome

Anatomical study of superior cluneal nerve entrapment

Association between intermittent low-back pain and superior cluneal nerve entrapment neuropathyFibrous adhesive entrapment of lumbosacral nerve roots as a cause of sciatica

Increased Fibrogenic Gene Expression in Multifidus Muscles of Patients With Chronic Versus Acute Lumbar Spine Pathology

Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury

Key Indicators of repetitive overuse-induced neuromuscular inflammation and fibrosis

Aging, Degenerative Changes, & Fibrosis

Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis

Structural and Functional Changes in the Coupling of Fascial Tissue, Skeletal Muscle, and Nerves During Aging

Alterations in quadriceps muscle cellular and molecular properties in adults with moderate knee osteoarthritis

The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis

The association of cervical sagittal alignment with adjacent segment degeneration

Fibrosis Development

Hypoxia-generated superoxide induces the development of the adhesion phenotype

Modulation of fibroblast proliferation by oxygen free radicals.

Low oxygen stimulates proliferation of fibroblasts seeded as single cells

Tensile mechanical properties of three-dimensional type I collagen extracellular matrices with varied microstructure

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